The main directions of development of scientific research on the complex problem "Microbiology" for 2011-2015

No., research council, task group

Direction of work for 2011-2015

Base organization, research institutions-executors

46.0 НС Research council for

microbiology

Protecting humans from infectious diseases. Molecular biological bases of activity, pathogenicity and variability of infectious agents, their antigenic and immunogenic properties. Molecular genetic mechanisms of evolution and speciation in prokaryotes. The relationship of pathogens with cytokine and interferon systems. Mechanisms of apoptosis and its suppression in infectious diseases. Persistence of infectious agents. Bioengineering technologies. Development of new drugs and methods for immunoprophylaxis, diagnostics (including nanodiagnostics) of infections. Development of new approaches to the creation of vaccines based on conservative antigens of microorganisms with a high degree of variability (HIV, influenza viruses, hepatitis C). Immunocorrection technologies. Relationships within bacterial communities, biofilm formation. The relationship of biofilm with the host's immune system. Microbiological monitoring of the environment. Ecology of pathogenic pathogens. Structural and functional organization of parasitic systems in natural foci of infections, including mixed ones. Biological safety of genetically modified microorganisms. Biological safety of nanomaterials.

FSBI "Gamaleya Research Institute of Epidemiology and Microbiology" of the Ministry of Health and Social Development of Russia;

FSBI "L.A. Tarasevich State Institute of Standardization and Control of Biomedical Preparations"

of the Ministry of Health and Social Development of Russia;

Research institutes of Rospotrebnadzor; Departments of Microbiology of Universities of the Ministry of Health and Social Development of Russia;

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences;

Institute of Molecular Biology of the RAS;

Lomonosov Moscow State University of the Ministry of Education and Science of Russia.

Task group 46.01. “Medical Microbiology and Molecular Biology of Microorganisms”

Structural and functional patterns of genome organization and vital activity of pathogens of acute and chronic infections. Pathogenic factors. Molecular mechanisms of interaction of microbial pathogens with eukaryotic cells. Antigens of microorganisms. Persistence of infectious agents. Classification and taxonomy of infectious agents.
 Development of new diagnostic methods, including nanodiagnostics. Relationships within bacterial communities, biofilm formation. Biodiversity of microorganisms. Molecular genetic mechanisms of evolution and speciation in prokaryotes. Genomic polymorphism of pathogenic bacteria. Development of genetically engineered subunit vaccines. Special medical microbiology. Human bacterial flora in normal and pathological conditions. Bioinformatics in the field of molecular biology of pathogenic microorganisms. Microbiological risks associated with nanotechnology.

FSBI "Gamaleya Research Institute of Epidemiology and Microbiology" of the Ministry of Health and Social Development of Russia;

Federal State Institution of Science "Moscow Research Institute of Epidemiology and Microbiology" of Rospotrebnadzor (Moscow);

Federal State Institution of Science

“Saint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology” of Rospotrebnadzor;

Research Institute of Children's Infections of the Federal Medical and Biological Agency;

Departments of Microbiology of Universities of the Ministry of Health and Social Development of Russia;

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences;

Institute of Molecular Biology of the RAS;

Lomonosov Moscow State University of the Ministry of Education and Science of Russia.

Task group 46.02

"Theoretical and applied infectious immunology"

Molecular genetic and cellular bases of anti-infectious immunity. Theoretical foundations of antiviral immunity. The relationship of the immune, system, cytokines and interferons with pathogens. Immunopathology in infectious processes. Genetic control of the immune response to mycobacteria. Intercellular interactions and apoptosis in the development of the immune response. The role of subpopulations of immunocompetent cells (Treg, Th9, Th22, Th17). Ligand-receptor relationships and molecular signaling mechanisms in the response of immunocompetent cells to infectious agents. The role of natural resistance in the development of adaptive immunity. Immune response to lipid antigens. The role of CD1. Immunomodulatory properties of biofilms. Theoretical foundations of immunoprophylaxis and immunotherapy. Creation of new generation preventive drugs (vaccines and adjuvants). Biotechnology of immunological drugs and methods of immunodiagnostics of infectious diseases. Creation of modified drugs: immunoglobulins, humanized and mini-antibodies, immunotoxins with targeted delivery.
 Influence of infectious agents, immunomodulators and antiviral drugs on stromal and hematopoietic progenitor cells. Creation of the technology for replacing damaged tissues using own cellular elements multiplied in vitro. Development of the system for assessing the immune status of the population.

FSBI "Gamaleya Research Institute of Epidemiology and Microbiology" of the Ministry of Health and Social Development of Russia;

FSBI "L.A. Tarasevich State Institute of Standardization and Control of Biomedical Preparations" of the Ministry of Health and Social Development of Russia;

Research Institute of Fundamental and Clinical Immunology of the Siberian Branch of the Russian Academy of Medical Sciences;

Federal State Institution of Science “Saint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology” of Rospotrebnadzor;

Research Institute of Influenza of the Ministry of Health and Social Development of Russia;

Federal State Institution of Science "Moscow Research Institute of Epidemiology and Microbiology" of Rospotrebnadzor (Moscow);

Mechnikov Research Institute of Vaccines and Serums of Russian Academy of Medical Sciences;

FSBI “D. I. Ivanovskiy Research Institute of Virology” of the Ministry of Health and Social Development of Russia; 

Chumakov Institute of Poliomyelitis and Viral Encephalitis of Russian Academy of Medical Sciences;

Central Research Institute of Tuberculosis of RAMS.

Task group 46.03

“Natural focal human infections”

Biological properties and taxonomy of pathogens of natural focal infections, including new and recurring ones. The origin of pathogens and their evolution. Heterogeneity of populations, their ecology in connection with the epizootic and epidemic manifestation of natural foci. Significance of modern molecular biological methods for the study of natural focal zoonoses.
 Genetic heterogeneity of hosts and its influence on the circulation of pathogens. Creation of a collection of cultures of the most important pathogens and molecular epidemiology of natural focal infections. Reservation mechanisms of pathogens. Functional patterns of mixed parasitic systems, epizootology and epidemiology of natural focal mixed infections. The influence of social factors on the etiological structure of natural foci. The intensity of contacts of the population with them in connection with the prediction of their epidemic manifestation. Development of laboratory methods for simultaneous serodiagnostics of a complex of natural focal infections. Principles and methods of complex prevention of natural focal infections.

FSBI "Gamaleya Research Institute of Epidemiology and Microbiology" of the Ministry of Health and Social Development of Russia;

State Institution “Omsk Research Institute of Natural Focal Infections” of Rospotrebnadzor;

Federal Government Healthcare Institution “Irkutsk Scientific Research Antiplague Institute”

of Rospotrebnadzor;

Vladivostok Institute of Epidemiology and Microbiology of the Siberian Branch of the Russian Academy of Medical Sciences;

Institute for Biological Instrumentation of the Ministry of Industry, Science and Technology of Russia;

Federal State Institution of Science “Saint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology” of Rospotrebnadzor;

State Institution of Science "Research Institute of Disinfectology" of the Ministry of Health and Social Development of Russia.

Task group 46.04

“Development and standardization of medical immunobiological preparations (MIBP) for the prevention and diagnosis of infectious diseases”

Development, improvement and standardization of MIBP for prevention, immunotherapy and diagnosis of infectious diseases. Creation of the system for assessing the quality of vaccines obtained by reproduction in  finite Vero cell line in terms of "foreign matter".
 Development of a new concentrated rabies vaccine using the finite Vero cell line. Improving methods for assessing the quality of vaccines for measles prevention. Study of the effectiveness of modern vaccines against strains of the Ural-Siberian genotype of tick-borne encephalitis virus. Improvement of the method for assessing the quality of tick-borne encephalitis vaccines by quantitative determination of specific viral antigen by the EIA method. Development and certification of methods for evaluating the first domestic vaccine against hemorrhagic fever with renal syndrome (HFRS) "Combi-HFRS-vac". Improvement of the system for assessing the quality of the pertussis component of complex vaccines. Improvement of methods for standardization and evaluation of drugs for the prevention of hepatitis A. Development of panels of positive specific serums for standardization and quality assessment of allergens and diagnostic test systems. Development of a new comprehensive method for identifying infected persons and monitoring persons from risk groups for tuberculosis in a dispensary.

FSBI "L.A. Tarasevich State Institute of Standardization and Control of Biomedical Preparations" of the Ministry of Health and Social Development of Russia;

Chumakov Institute of Poliomyelitis and Viral Encephalitis of Russian Academy of Medical Sciences; Mechnikov Research Institute of Vaccines and Serums of Russian Academy of Medical Sciences;

Federal State Institution “48th Central Research Institute of the Ministry of Defense of the Russian Federation”;

Federal State Institution of Science State Research Center for Virology and Biotechnology “Vektor” of Rospotrebnadzor;

FSBI “D. I. Ivanovskiy Research Institute of Virology” of the Ministry of Health and Social Development of Russia; 

Research Institute of Phthisiopulmonology of Sechenov First Moscow State Medical University of the Ministry of Health and Social Development of Russia;

Enterprises for the production of bacterial preparations of the Russian Academy of Medical Sciences and the Ministry of Health and Social Development of Russia, Rospotrebnadzor, FMBA.