Practical implementation of scientific achievements

The implementation of the results of scientific research, their implementation in the diagnosis, prevention and treatment of infectious diseases, the focus of a number of scientific developments on the daily needs of practical health care, sanitary and epidemiological surveillance and veterinary medicine are important components of the Institute's activities.

In 2002-2013, 85 editions of guidelines, instructions and manuals were prepared. 

  • Organization of control and methods for detecting Listeria monocytogenes bacteria in food. Approved by the Russian Ministry of Health on April 22, 2002. 

  • Determination of specific antigens — Helicobacter pylori markers in biological material of infected people and in food products by coagglutination reaction. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on May 15, 2002

  • Application of a set of salmonella diagnostic agents for B, C1, C2, D, E serogroups in the coagglutination reaction. Approved by the Veterinary Department of the Ministry of Agriculture of the Russian Federation on October 17, 2002.

  • Guidelines for conducting preclinical studies of the cytokine-inducing activity of antiviral drugs. Approved by the Pharmaceutical Committee of the Ministry of Health of Russia on December 31, 2002.

  • Guidance on the use of diagnostic agents for determining of the O-antigen of Helicobacter pylori by the coagglutination reaction. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on January 9, 2003

  • Determination of individual sensitivity of the organism to interferons, other cytokines, and interferon inducers. Approved by the Pharmaceutical Committee of the Ministry of Health of Russia on January 31, 2003

  • Laboratory diagnostics of intestinal dysbiosis (medicinal standards). Approved by the Russian Ministry of Health on February 10, 2003.

  • Immunomodulating and antiviral drug Viferon in the treatment of children and adults who often suffer from viral and bacterial infections.

  • Immunocorrection with leukinferon in pulmonary tuberculosis.

  • Prevention and laboratory diagnosis of human brucellosis. Guidelines MU 3.1.7.1189-03.

  • Methodology for determining and using control levels of ARD incidence for a quick assessment of the state of the epidemic situation and timely implementation of adequate preventive measures in Moscow. Approved by the chief physician of the Moscow State Sanitary and Epidemiological Service on September 8, 2003.

  • Microbiological and molecular genetic evaluation of food products obtained using genetically modified microorganisms. Approved by the Chief State Sanitary Doctor of the Russian Federation on February 1, 2004.

  • Guidelines for planning measures to counteract the HIV epidemic among intravenous drug users. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on March 30, 2004

  • Toxoplasmosis (etiology, epidemiology, clinical and diagnostic aspects, treatment, prevention). Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on September 17, 2004

  • The procedure and organization of control over food products obtained from / or using genetically modified microorganisms and microorganisms with genetically modified analogues. Approved by the Chief State Sanitary Doctor of the Russian Federation on October 1, 2004.

  • Serological method for the differential diagnosis of C. pneumoniae and C. trachomatis. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on November 18, 2004

  • Organization of epidemiological surveillance of tick-borne rickettsiosis. Approved by the Chief State Sanitary Doctor of the Russian Federation in 2004.

  • Implementation of preclinical studies of the modulating effect of drugs on the proliferation of human blood vessel endothelial cell culture. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on March 24, 2005

  • Revealing and identification of bacteria of the Burkholderia cepacia complex. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on May 20, 2005

  • Testing of virucidal activity of disinfectants directed against human hepatitis B virus by in vivo modeling of hepatitis B in ducks. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on May 20, 2005 and and the Federal Center for Animal Health, 2005.

  • Clinical and laboratory diagnostics of parenteral viral hepatitis and the procedure for testing for the hepatitis B and C viruses in patients of specialized psychiatric institutions in the Moscow region. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on June 17, 2005

  • Guidelines for the study of the specific antiviral activity of pharmacological substances (2 editions).

  • Guidelines for studying the specific activity of interferon inducers.

  • Procedure and organization of control over food products obtained using genetically modified microorganisms. Approved by the Russian Ministry of Health and Social Development, 2005

  • Methodological manual "Avian influenza and the problem of a pandemic". Approved by the Moscow Department of Healthcare on December 5, 2005

  • Organization of computational studies on the problem of prevention, localization, and elimination of natural smallpox epidemics (outbreaks) on the territory of the country.

  • The reaction of coagglutination in intestinal infectious diseases. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on Fenruary 9, 2006

  • Guidelines for the identification and determination of pathogenic factors of Staphylococcus hyicus - the causative agent of exudative epidermis (weeping eczema) in pigs. Approved by the "Infectious pathology of animals" section of the Department of Veterinary Medicine of the Russian Academy of Agricultural Sciences on March 30, 2006

  • Prevention of infectious diseases. Epidemiological surveillance of tularemia. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on May 11, 2006.

  • Methicillin-resistant Staphylococcus aureus - causative agents of nosocomial infections. Approved by Rospotrebnadzor on June 28, 2006

  • Diagnostics and prognosis of the development of acute intestinal infections. Approved by the Moscow Department of Healthcare, 2006

  • Medical technology "Monitoring of pregnant women with viral infections of the herpes family". Approved by the Federal Service for Surveillance in Healthcare and Social Development, 2006

  • Diagnostics of HIV infection and concomitant viral infections in pregnant women and management of labor in women with viral infections. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on December 14, 2006

  • Application of a computer program for calculating serum dilutions giving 50% saturation of the sorbent with antibodies in enzyme immunoassay. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on February 22, 2007

  • Guidelines for the detection of Legionella pneumophila bacteria in environmental objects. Approved by Rospotrebnadzor and introduced on August 1, 2007.

  • Herpesvirus infections. Approved by the Moscow Department of Healthcare in October 2007

  • Infections transmitted by ixodid ticks in the Perm region (etiology, epidemiology, pathogenesis, clinical picture, diagnosis, treatment and prevention). Published by the Perm State Medical Academy named after academician E.A. Wagner, 2007

  • The procedure for organization of control over food products obtained from / or using genetically modified microorganisms and microorganisms with genetically modified analogues. Guidelines MU 2.3.2.2303-07.

  • Methodological manual for intensive care of patients with tuberculosis. Guidelines UMO-954-D dated December 26, 2007

  • Cultivation of primary culture of cattle endothelium cells. Approved by the Academic Council of the All-Russian Research Institute of Experimental Veterinary Medicine named after Ya.R. Kovalenko RAAS on September 2, 2008.

  • Epidemiological surveillance of legionella infection. Guidelines MU 3.1.2.2412-08.

  • Prevention of parenteral viral hepatitis and opportunistic infections in women of fertile age. Approved by the Methodical Council of the Institute for Advanced Training of Doctors of the Ministry of Health and Social Development of the Chuvash Republic, Cheboksary, 2008

  • Infection caused by the type 6 herpesvirus (epidemiology, clinical picture, diagnosis). Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on September 25, 2008

  • A method for complex control of the functional activity of cellular immunity during vaccination against hepatitis. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on October 27, 2008

  • Obtaining attenuated strains of bacteria as a result of site-specific mutagenesis of the gene encoding L, D-carboxypeptidase. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on October 27, 2008

  • Production of recombinant proteins phospholipase C and sphingomyelinase Bacillus anthracis. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on November 13, 2008

  • A method for complex control of the functional activity of cellular immunity in the management of patients infected with the hepatitis B virus. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on December 5, 2008

  • Features of using Mancini single radial immunodiffusion assay in conditions of metabolic disturbances. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on December 5, 2008

  • Manufacturing and control of a diagnostic test system for the determination of M. pneumoniae antigens in enzyme-linked immunosorbent assay. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on March 19, 2009

  • Manufacturing and control of a diagnostic test system for the determination of M. hominis antigens in enzyme-linked immunosorbent assay. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on March 19, 2009

  • Determination of bacterial endotoxins in biological products using cell line 293, expressing Toll-like receptor 4. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on March 19, 2009

  • Diagnostics of mycoplasma infections in non-gonococcal urethritis in men. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on April 17, 2009

  • Candida fungi (methods of isolation, identification at the species level and determination of sensitivity to antifungal drugs). Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on April 17, 2009

  • The procedure of medical institutions of infectious profile operation in the context of an influenza epidemic. Part 1. Approved by the Moscow Department of Healthcare in 2009

  • Methodological manual "Pneumocystosis - actual immunodeficiency-associated infection (epidemiology, clinical presentation, diagnostics and treatment)".

  • Method for detecting C.trachomatis DNA in blood serum by quantitative RT-PCR. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology RAMS on February 25, 2010

  • Methodological instructions "Microbiological and molecular genetic assessment of the impact of nanomaterials on representatives of microbiocenosis". Guidelines MU 1.2.2634-10. Moscow, Federal Center for Hygiene and Epidemiology of Rospotrebnadzor, 2010

  • Methodological instructions "Medical and biological assessment of the safety of nanomaterials". Guidelines MU 1.2.2635-10. Moscow, Federal Center for Hygiene and Epidemiology of Rospotrebnadzor, 2010

  • Detection of antigen of bacteria Legionella pneumophila serogroup 1 in clinical material by immunochromatographic method. Guidelines MR 01 / 14633-8-34. Moscow, 2010

  • Pneumocystosis - actual immunodeficiency-associated infection (epidemiology, clinical presentation, diagnostics and treatment). Guidelines MR 3.2.0003-10. Moscow, 2010

  • Immunization with the "Vitagerpavac" vaccine (herpes cultured inactivated dry) for the prevention of recurrence of infection caused by herpes viruses of types 1 and 2. Guidelines MR 3.3.1.0002-10. Moscow, Rospotrebnadzor, 2010

  • 2009-10 influenza epidemic in Moscow - assessment of the epidemic situation, tactics of complex therapy for patients with influenza A/H1N1sw/2009 and prevention of nosocomial infection. Moscow, 2010

  • Sanitary and Epidemiological Rules of SP 3.1.7.2613-10 "Prevention of brucellosis". Approved by the Chief State Sanitary Doctor of the Russian Federation on April 26, 2010.

  • Sanitary and Epidemiological Rules SP 3.1.2.2626-10 "Prevention of Legionellosis". Approved by the Chief State Sanitary Doctor of the Russian Federation, 2010.

  • Sanitary and Epidemiological Rules SP 3.1.7.2642-10 "Prevention of tularemia". Approved by the resolution of Rospotrebnadzor on May 31, 2010.

  • Sanitary and Epidemiological Rules SP 3.1.7.2815-10 "Prevention of ornithosis". Approved by the Chief State Sanitary Doctor of the Russian Federation on December 29, 2010.

  • Sanitary and Epidemiological Rules SP 3.1.7.2835-11 "Prevention of leptospirosis infection in humans." Approved by the Chief State Sanitary Doctor of the Russian Federation on January 20, 2011. 

  • Guidelines. Evaluation of the viability of biofilms formed by Yersinia enterocolytica using a two-component ultraviolet dye. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on April 7, 2011

  • Assessment of physical effects (electromagnetic radiation from low-temperature plasma) on the viability of intracellular parasites and host cells. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on July 14, 2011

  • Use of a test system based on human eukaryotic cells of the HEK-293 hNOD1 line to determine the biological activity of the NOD1 receptor ligands. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on July 14, 2011

  • Creation of strains-producers of Aggregatibacter actinomycetemcomitans, suitable for the development of methods for the diagnosis and treatment of aggressive forms of periodontitis. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on September 22, 2011

  • Application of non-isothermal "cold" atmospheric pressure plasma against pathogenic bacteria. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on October 27, 2011

  • Use of enzyme immunoassay to assess the conformational transformations of Fc fragments of antibody molecules. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on October 27, 2011

  • Methods for assessing the immunogenicity of recombinant mutant HBsAg. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on November 15, 2011

  • Methods for the selection of recombinant HBsAg mutants for the creation of a polyvaccine against hepatitis B. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on November 15, 2011 

  • Methodological recommendations "The use of cycloferon (meglumine acridone acetate) in the complex therapy of patients with bronchial asthma in acute respiratory infections" edited by A.G. Chuchalin and F.I. Ershov. Approved by the Moscow Department of Healthcare on March 20, 2012

  • Obtaining pilot industrial samples of compositions of molecular adjuvants to increase the efficiency of antibacterial and antiviral vaccines. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia in 2012

  • Tactics for the prevention of viral hepatitis B and C among medical workers of anti-tuberculosis institutions and patients with tuberculosis. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on June 20, 2012

  • Development of experimental model systems for assessing the immunomodulatory activity of molecular adjuvants in vitro and in vivo. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on July 27, 2012

  • Method for detection of highly virulent strains of Legionella. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on November 22, 2012

  • A method for detecting avirulent bacteria Bordetella pertussis formed as a result of insertions of IS-elements 481 and 1002 into the virulence operon bvgAS in patients with atypical forms of whooping cough. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development of Russia on November 22, 2012

  • Determination of the toxicity of bacterial pathogenicity factors using the yeast Saccharomyces cerevisiae. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology on January 25, 2013

  • Quantification of the impact of the parameters of countermeasures on the epidemic process of hepatitis B based on mathematical modeling. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology on July 25, 2013

  • Assessment of the prevalence of "latent" forms of HBV infection among patients of various types of departments of a multidisciplinary hospital. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology on July 25, 2013 

  • Prevention of viral hepatitis B and C among patients and staff of drug treatment hospitals and early treatment centers in Moscow. Approved by the Council for the Practical Implementation of Scientific Achievements of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology on September 5, 2013 


In 1999-2013, Institute employees received 48 patents.

  • Ridostin interferon inductor.

  • Gel for wounds healing.

  • Ointment for the pyoderma treatment.

  • A method for assessing the immunomodulatory activity of drugs.

  • A method of obtaining a diagnostic agent for the detection of Helicobacter pylori in the coagglutination reaction.

  • A method for pneumocysts isolating.

  • A non-invasive method for detecting Helicobacter pylori in cases of duodenal ulcer disease.

  • A method for diagnosing the pathology of cellular immunity in chronic viral infections.

  • A method for differentiation of Listeria monocytogenes cultures.

  • Therapeutic composition and methods (USA).

  • A method for in vivo determination of cytoproliferative factor in the body of aging mammals and humans.

  • Immunomodulator - metabolic - detoxifier - adaptogen - radioprotector.

  • A method for the treatment of urogenital infections.

  • The phenomenon of aging factor accumulation in mammals.

  • A method for assessing the protective properties of immunomodulating drugs.

  • Non-infectious adenovirus, as a vector for replacement therapy of angiogenesis disorders, providing efficient synthesis of human angiogenin in transfected human cells; a method for the induction of angiogenin, a method for the treatment of ischemic disease, compositions for the induction of angiogenesis in ischemic disease.

  • Recombinant plasmid DNA encoding the synthesis of the recombinant protein TUL4spCBD, the producer strain, the recombinant protein and the method for its production, the method for the production of specific antibodies to the protein.

  • Recombinant protein LACspCBD, which has beta-galactosidase activity and the ability to spontaneously bind to a cellulose-containing sorbent, recombinant plasmid DNA encoding the synthesis of a recombinant protein, a producer strain, a method for producing an immobilized protein on cellulose and a method for lactose digestion.

  • A method for detecting endotoxins of gram-negative bacteria.

  • Means of prevention and correction of immunodeficiency conditions.

  • Means for the prevention and treatment of viral diseases and a method for the prevention and treatment of viral diseases.

  • A method for blocking a chronic integrative infection caused by the human immunodeficiency virus.

  • A method of creating a recombinant avian adenovirus for vaccination and gene therapy.

  • Recombinant plasmid (variants), Escherichia coli strain (variants) - producer of chimeric proteins, chimeric protein (variants), method of immobilization, concentration and purification of recombinant proteins on cellulose, method of immobilization of recombinant proteins on polystyrene carriers.

  • A method of obtaining Pneumocystis carinii for diagnostic test systems.

  • Recombinant plasmid pD5spGBD, Escherichia coli strain - producer of recombinant D5-GBD protein, recombinant D5-GBD protein and a method for its production, a method for studying the binding of D5-GBD protein with antibodies of sera of patients, a method for producing specific antibodies to D5-GBD protein.

  • Recombinant plasmid pD1spGBD, Escherichia coli strain - producer of recombinant D1-GBD protein, recombinant D1-GBD protein and a method for its production, a method for studying the binding of D1-GBD protein with antibodies of sera of patients, a method for obtaining specific antibodies to D1-GBD protein.

  • Recombinant plasmid pD4spGBD, Escherichia coli strain - producer of recombinant D4-GBD protein, recombinant D4-GBD protein and a method for its production, a method for studying the binding of D4-GBD protein with serum antibodies of patients, a method for obtaining specific antibodies to D4-GBD protein.

  • N-substituted derivatives of oxamic acid thiohydrazides, a method for their preparation and their use.

  • Biologically active substances suppressing pathogenic bacteria.

  • A method of obtaining oral rabies virus vaccine.

  • Recombinant plasmid pAg85A-CBD, E. coli strain (pREP4, pAg85A-CBD), chimeric protein pAg85A-CBD and their application.

  • Recombinant plasmid pCFP10-CBD, E. coli strain (pREP4, pCFP10-CBD), chimeric protein pCFP10-CBD and their application.

  • Recombinant plasmid pESAT6-CBD, E. coli strain (pREP4, pESAT6-CBD), chimeric protein pESAT6-CBD and their application.

  • Method for stimulating the regeneration of skin and mucous membranes defects and a medicinal product for its implementation.

  • Attenuated Bordetella pertussis bacteria, pertussis vaccine.

  • Method for purification of recombinant mammalian and human adenoviruses.

  • Method for determining the ability of microorganisms to form biofilms on the surface of solid phase.

  • Method of targeted delivery of osteoplastic materials containing growth and regeneration factors of bone tissue to the area of the alveolar bone defect.

  • Recombinant adenoviral nanoparticle, pharmaceutical composition for the prevention or therapy of influenza (options), method for the prevention or therapy of influenza.

  • Method of obtaining a demineralized bone matrix in the form of a crumb.

  • Method of obtaining protein-mineral composition containing recombinant Collbd-BMP-2 protein.

  • Use of indol-3-yl-glyoxylamides for suppression of chlamydial infection.

  • Biologically active substances that suppress pathogenic bacteria, and method of inhibiting type III secretion in pathogenic bacteria.

  • Recombinant plasmid, recombinant strain, recombinant BMP-7 protein and method for isolation of recombinant protein in dimeric form.

  • Recombinant plasmid, recombinant BMP-2 protein and method for isolation of recombinant protein in dimeric form.

  • Pharmaceutical composition based on ligands of pattern recognition receptors, method of its use as an immunostimulant for the treatment of infections caused by bacterial and viral pathogens, method of its use as an adjuvant in vaccines.

  • Method for diagnosing pertussis and determining avirulent mutants of the pathogen and a diagnostic kit. 

Based on the results of the tests, on June 10, 2002, a positive decision was made by L.A. Tarasevich State Institute of Standardization and Control of Biomedical Preparations of the Ministry of Health of Russia for the use in practice of an immunofluorescent test system for detecting ureaplasmas in biological material. Serial production was started.

By the decree of the Gosstandart of Russia dated June 12, 2002, the sanitary and hygienic standards "Methods for the detection and determination of Listeria monocytogenes bacteria" were adopted and put into effect.

On October 17, 2002 Specifications for the "Set of Salmonella diagnosticums of B, C1, C2, D, E serogroups for the coagglutination reaction" were agree upon with the Department of Veterinary Medicine of the Ministry of Agriculture of the Russian Federation. 

On November 12, 2002, the Anti-Plague Center of the Ministry of Health of Russia approved an information letter on the analysis of the incidence of tularemia in people in the Russian Federation using epidemiological maps for examining tularemia foci.

The Moscow Health Committee approved an information letter “On the results of the epidemic season for influenza and ARVI in 2001-2002, and the forecast for 2003 ", an order “On the introduction of restrictive and anti-epidemic measures in the territory of Zelenograd Autonomous Okrug due to the rise in the incidence of influenza and ARVI" was issued.

By order of the Ministry of Health of Russia No. 231 of June 9, 2003, the industry standard "Patient Management Protocol. Intestinal dysbacteriosis " was approved.

In 2003, industrial production of Salmonella diagnosticums of B, C1, C2, D, E serogroups was organized for use in the coagglutination reaction when diagnosing salmonellosis, monitoring food, feed and environmental objects in veterinary laboratories.

Registration certificates for the industrial production and medical use of drugs Kagocel (for the treatment of influenza, herpes, ARVI) and Phosprenyl (for use in veterinary medicine for the treatment of viral infections) were obtained.

On October 21, 2004, the Federal Service for Surveillance in Healthcare and Social Development approved the normative and technical documentation for "Liquid brucellosis diagnosticum for agglutination reaction". Since 2005, the Medgamal branch has started manufacturing and selling the drug.

On November 11, 2005, a registration certificate was received for the Hepastrip test system with the Hepablock confirmation test for the diagnosis of viral hepatitis B.

On September 10, 2006, the Chief State Sanitary Doctor of the Russian Federation signed and sent to the subjects of the Russian Federation an official letter "On the prevention of tetanus in the Russian Federation".

A permit was obtained for clinical trials of the drug Fortepren for the prevention and treatment of herpes infection.

By the order of the Ministry of Health and Social Development of the Russian Federation of July 4, 2008, the immunoenzymometric assay "Toxoplastrip" was approved for use for the diagnosis of toxoplasmosis.

In veterinary practice, the drug Gamapren, which has antiviral and immunomodulatory activity, was approved for use.

At various stages of clinical trials, there are new promising drugs and prophylactic agents: Gamabiol balm, Labdalene cream and betulin (in veterinary practice), Kagocel (prevention of influenza and ARVI in children), Allokin (treatment of papillomatous viral diseases). 

Orders of Roszdravnadzor of December 3, 2009 alowed the production, sale and use of medical devices "A set of reagents for conducting an indirect fluorescence reaction for the detection of specific antigens of Pneumocystis carinii — PneumocystofluoAGdiagnostics" and "A set of reagents for the immunoenzyme detection of immunoglobulins M and G to Pneumocystis carinii — PneumocystoStrip " produced by the Medgamal branch of Gamaleya Research Institute of Epidemiology and Microbiology of the Russian Academy of Medical Sciences.

A certificate was received on depositing of the author's strain of the causative agent of natural focal infection — Coxiella burnetii AM-2010 in the All-Russian Museum of Rickettsial Cultures, February 16, 2012. 

Certificates on depositing 95 new nucleotide sequences of gene fragments of pathogenic microorganisms in GenBank was received, 2012.